Centromeric Chromatin: Histone deviants
نویسندگان
چکیده
منابع مشابه
Centromeric Chromatin: Histone deviants
Highly variant histones are targeted to specialized chromatin domains, such as the centromere where they have an essential role in the segregation of sister chromatids at mitosis.
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Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specifi...
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Studies in several organisms have shown that eukaryotic centromere regions contain proteins involved in chromosome inheritance functions such as centromere structure, heterochromatin assembly and sister chromatid cohesion. Mutation, inhibition, knockout and reciprocal epistasis experiments have revealed functions for many centromere region proteins and their order in the centromere assembly pat...
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n page 765, Ohzeki et al. present evidence for sequence specificity in assembling chromatin at mammalian centromeres. The sequence requirements imply that construction of centromeric chromatin is more than an epigenetic process. O Centromeric chromatin assembles at AT-rich repeats called ␣ satellite sequences, or alphoids. Type I alphoids contain boxes for the binding of CENP-B, one of several ...
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Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein requir...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1995
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(95)00088-1